top of page
  • Writer's pictureKirk Hartley

Sponsored Research – Mayo Doctors Report on Bias, Payments and Medical Articles

Sponsored research is a short-hand term for situations in which researchers also receive payments from pharma or other entities. Lots of positions are taken on the topic, and the area is fraught with arguments about what is "good," "right," and "practical."

The topic has new grist for argument now that ScienceDaily for March 20 brings news of a study from Mayo Clinic doctors regarding the links between positive medical reviews and payments from pharma. The article certainly provides disquieting news on undisclosed conflicts of interest. The overall numbers make one stop and think, but overgeneralzing seems not wise.

"ScienceDaily (Mar. 20, 2010) — Virtually all (94%) of the scientific authors who provided positive results for the anti-diabetic drug rosiglitazone had financial relationships with pharmaceutical companies, according to research published online in the British Medical Journal.

While the study acknowledges that financial relationships may not necessarily be the reason for positive research results, it concludes that further reform is needed to ensure trust in scientific work.

In 2007, a large scale review of rosiglitazone showed that use of the drug led to a significant increased risk of heart attacks. This in turn led to further studies and commentaries by scientists about the safety of rosiglitazone. Policies were also developed to encourage disclosure of such financial conflicts of interest.

But whether these policies have made any impact on the association between financial conflicts of interest and views expressed in scientific reports is still unknown.

So researchers at the Mayo Clinic in the USA assessed over 200 articles on rosiglitazone to explore a possible link between authors’ financial conflicts of interest and their views on the safety of the drug.

They found that almost half of the study authors (45%) had financial conflicts of interest and almost a quarter of these (23%) did not disclose this information. Three studies included in the latter group published a statement declaring no conflicts of interest.

Almost all (94%) authors who had favourable views on the safety of rosiglitazone were more likely to have a financial conflict of interest with a pharmaceutical company than were authors who had unfavourable views.

The researchers conclude by saying: "Disclosure rates for financial conflicts of interest were unexpectedly low, and there was a clear and strong link between the orientation of authors’ expressed views on the rosiglitazone controversy and their financial conflicts of interest with pharmaceutical companies."

"These findings, while not necessarily causal, underscore the need for further progress in reporting in order for the scientific record to be trusted," they add."

The article’s citation is:

A. T Wang, C. P McCoy, M. H. Murad, V. M Montori. Association between industry affiliation and position on cardiovascular risk with rosiglitazone: cross sectional systematic review. British Medical Journal, 2010; 340 (mar18 1): c1344 DOI: 10.1136/bmj.c1344

2 views0 comments

Recent Posts

See All


bottom of page