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  • Writer's pictureKirk Hartley

Changes in Science – 1986 Cleveland Clinic Case Study of a Cystic Mesothelioma

Times and science change. It appears the Cleveland Clinic apparently recently brought online old editions of its own Cleveland Clinic Journal of Medicine. The materials online now incluede, for example, a 1986 case report on a cystic peritoneal mesothelioma. According to the abstract, a literature search at that time yielded 20 other case reports. See below for the abstract.

"Cystic mesothelioma of the peritoneum

Report of a case with multiple recurrences and review of the literature1

Janet M. Miles, M.D. and William R. Hart, M.D., Section Editor

Department of Pathology, The Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44106

James T. McMahon, Ph.D.

+ Author Affiliations


A case of cystic peritoneal mesothelioma with repeated local recurrences is presented. Ultrastructural and immunohistochemical studies confirmed the mesothelial character of the lesion. The literature was reviewed and 20 previously reported cases tabulated. Cystic mesothelioma is a relatively “benign” tumor characterized by frequent intra-abdominal recurrences without distant metastases. Morbidity associated with the lesion is due to local tumor recurrence. Patients are usually women of reproductive age with complaints of abdominal pain. Some tumors are discovered initially as incidental findings. No specific factors are helpful in predicting which tumors are most likely to recur. Recurrences are independent of lesion size at initial or recurrent presentation, adequacy of tumor resection, or the use of adjunctive therapy. No consistent etiologic factor has yet been identified in the pathogenesis of this rare neoplasm.

Index terms:

Mesothelioma Pathology features Peritoneal neoplasms

↵1 Department of Pathology, The Cleveland Clinic Foundation.

Received September 1985.

Accepted November 1985.

Copyright© 1986 The Cleveland Clinic Foundation"

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